Diazepam is N-demethylated by CYP3A4 and 2C19 on the active metabolite N-desmethyldiazepam, and is also hydroxylated by CYP3A4 towards the Lively metabolite temazepam. N-desmethyldiazepam and temazepam are both of those additional metabolized to oxazepam. Temazepam and oxazepam are mainly eliminated by glucuronidation.Prevent ingesting grapefruit o
Diazepam and its metabolites are excreted primarily while in the urine, predominantly as their glucuronide conjugates. The clearance of diazepam is twenty to 30 mL/min in youthful adults. Diazepam accumulates upon numerous dosing and There may be some proof the terminal elimination half-lifetime is a bit prolonged.Siga atentamente las instrucciones
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